Project Title |
Investigator |
Program Area |
---|---|---|
Innovative Approaches to Address Chemoresistance in Prostate Cancer: Integrating Electrokinetic and Microfluidic Technologies |
Adams, Tayloria |
Biotechnology, Imaging & Drug Development |
Phase IB, open-label trial of dual cytotoxic and immune-stimulatory gene therapy in combination with G-CSF for the treatment of resectable, recurrent glioblastoma (GBM) |
Bota, Daniela |
Biotechnology, Imaging & Drug Development |
Innate immune agonist codrugs for cancer immunotherapy. |
Burke, Thomas |
Biotechnology, Imaging & Drug Development |
Epcoritamab consolidation in patients with chronic lymphocytic leukemia who are in remission on continuous BTK inhibitors |
Coombs, Catherine |
Biotechnology, Imaging & Drug Development |
Enhancing CAR T cell activity by eliminating branched N-glycans |
Demetriou, Michael |
Biotechnology, Imaging & Drug Development |
Targeting neoplastic cell fate transitions through adhesome signaling |
Downing, Timothy |
Biotechnology, Imaging & Drug Development |
Enhancing the efficacy of radiation therapy by surgically targeted radiation-sensitizer loaded hydrogels:translation of in vitro results to a post-resection rat brain tumor model. |
Hirschberg, Henry |
Biotechnology, Imaging & Drug Development |
Peritoneal lavage exosomes gene signature in gastric cancer peritoneal carcinomatosis |
Senthil, Maheswari |
Biotechnology, Imaging & Drug Development |
Exploring Lipid Metabolism in NAFLD-HCC Transition Using Stem Cell Derived Hepatocytes |
Smith, Quinton |
Biotechnology, Imaging & Drug Development |
Single Molecule Dissection of Cancer-Associated Kinase Mutants |
Weiss,Gregory |
Biotechnology, Imaging & Drug Development |
A novel gut-liver axis as a risk factor for liver cancer |
Hang, Cholsoon |
Systems, Pathways & Targets |
Regulatory effects of Xist on the development of female and male colorectal cancer |
Kong, Mei |
Systems, Pathways & Targets |
Health disparities and early-onset HER2+ breast cancer in Vietnamese women |
Lawson, Devon |
Systems, Pathways & Targets |
Estrogen-Induced Oncogenic RNA Translation in Young Women's Tumors |
Lee, Gina |
Systems, Pathways & Targets |
Characterization of the immune response to neoadjuvant anti-PD-1 and -LAG3 therapy in Stage 3 melanoma |
Marangoni, Francesco |
Systems, Pathways & Targets |
Investigation of Microprotein Contributions to Pancreatic Ductal Adenocarcinoma |
Martinez, Thomas |
Systems, Pathways & Targets |
Adjuvant Sacituzumab Govitecan plus Nivolumab in Patients with Muscle-Invasive Urothelial Carcinoma at High-Risk for Cancer Recurrence who are ctDNA positive. |
Mar, Nataliya |
Systems, Pathways & Targets |
Establishment of a model system to elucidate mechanisms of response and resistance to engineered T-cell therapy in lymphoma |
Sworder, Brian |
Systems, Pathways & Targets |
HMGB2 Regulation of Anti-tumor T Cell Immunity |
Tinoco, Roberto |
Systems, Pathways & Targets |
Study the role of mutated NF2 in neurofibromatosis type 2 cancer |
Wang, Wengi |
Systems, Pathways & Targets |
Repurposing Riluzole for Augmenting Brain-Derived Neuropathic Factor (BDNF) Levels and Cognitive Function in Breast Cancer Patients Experiencing Cancer-Related Cognitive Impairment: An Interventional Pilot Clinical Trial |
Chan, Alexandre |
Cancer Control |
Financial Implications of a Pediatric/Adolescent/Young Adult (AYA) Cancer Diagnosis on a Patient's Quality of Life and Health Outcomes |
Morales, Sonia |
Cancer Control |
Project Title |
Investigator |
Program Area |
---|---|---|
Quantifying Transarterial Embolization Outcome Using Optical Molecular Imaging |
Abi-Jaoudeh, Nadine |
Biotechnology, Imaging & Drug Development |
Elucidating the Role of Gut Microbiome in Tamoxifen Pharmacokinetics |
Bess, Elizabeth |
Biotechnology, Imaging & Drug Development |
Innate Immune Agonist Codrugs for Cancer Immunotherapy |
Burke, Thomas |
Biotechnology, Imaging & Drug Development |
New Strategies to Overcome Therapeutic Resistance in Pancreatic Cancer |
Edinger, Aimee |
Biotechnology, Imaging & Drug Development |
Flexible Fiber-Based Laser Micro-Biopsy Platform for Minimally-Invasive Tissue Collection and Processing During Cancer Surgery |
Eng, Oliver |
Biotechnology, Imaging & Drug Development |
Multiomic Study of Merkel Cell Carcinoma (MCC) Heterogeneity at the Single Cell Level |
Gao, Ling |
Biotechnology, Imaging & Drug Development |
Quadruple Targeting Fabs (QT-Fab) for Pancreatic Cancer Treatment: Bispecific Fabs Conjugated to Two Anti-Cancer Therapeutics |
Weiss, Gregory |
Biotechnology, Imaging & Drug Development |
“Image-guided Precision Radiotherapy” Team Science Seed Grant |
Xiang, Liangzhong |
Biotechnology, Imaging & Drug Development |
The Role of Vitamin D on Mast Cell Activation and Neuroinflammation in Paclitaxel-Induced Peripheral Neuropathy |
Yun, Hyun Don |
Biotechnology, Imaging & Drug Development |
Exploiting USP7 Inhibitors as a Therapeutic Approach in Osteosarcoma |
Benavente, Claudia |
Systems, Pathways & Targets |
A Phase II Study of Adding Pitavastatin to Venetoclax-Based Therapy in Acute Myeloid Leukemia (AML) |
Brem, Elizabeth |
Systems, Pathways & Targets |
Phase I Clinical Trial Using Donor-derived BK Virus-specific T-cells (BK-VSTs) for Patients Who Develop Hemorrhagic Cystitis after Allogeneic Stem Cell Transplantation (PIVOT) |
Ciurea, Stefan |
Systems, Pathways & Targets |
Neuroblastoma with Resistance to Chemotherapy: A Therapeutic Strategy Based on Mitochondrial-Mediated Ferroptosis |
Kenney, M. Crisitina |
Systems, Pathways & Targets |
A Phase 1b Feasibility Trial of Response Adapted Neoadjuvant Therapy in Gastric Cancer (RANT-GC) |
Dayyani, Farshid |
Systems, Pathways & Targets |
Connecting Mevalonate Pathway with Oncogene Transcriptional Networks in Leukemia |
Fruman, David |
Systems, Pathways & Targets |
Cell Therapy for Muscle Atrophy Following Irradiation in Rhabdomyosarcoma |
Hicks, Michael |
Systems, Pathways & Targets |
Glucocorticoid Pre-Treatment of Mouse And Human Donor Grafts for Prevention of GraftVersus-Host Disease While Maintaining Graft-Versus-Leukemia Response in Allogeneic Hematopoietic Cell Transplantation |
Inlay, Matthew |
Systems, Pathways & Targets |
Evaluating BRCA-Mediated Ovarian Tumorigenesis and Metastasis Through Spatial Mapping and RNA-Sequencing at the Single-Cell Level |
Kessenbrock, Kai |
Systems, Pathways & Targets |
Using Single Cell Transcriptomics to Elucidate Fundamental Mechanisms of Cancer Surveillance |
Lander, Arthur |
Systems, Pathways & Targets |
Targeting Breast Cancer Metastasis with Natural Killer Cells |
Lawson, Devon |
Systems, Pathways & Targets |
A Pilot Study to Assess The Diversity Of Gut Microbiome in Metastatic Non-Small Cell Lung Cancer (NSCLC) in Correlation to Treatment Effects and Adverse Effects |
Nagasaka, Misako |
Systems, Pathways & Targets |
Is There a Link Between Prostate Cancer and HPV? |
Cozen, Wendy |
Cancer Control |
Translating Goal-Focused Emotion Regulation Therapy to Young Adults Across Cancer Diagnoses |
Hoyt, Michael |
Cancer Control |
Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Patients with Chronic Myeloid Leukemia |
Jafari, Mahtab |
Cancer Control |
Stress and Coping in Asian Americans with Advanced/Metastatic Cancer |
Kim, Jacqueline |
Cancer Control |
Identifying early metabolic-hormonal signals of young-onset colorectal cancer based on UC Health Data Warehouse: a blended machine learning approach |
Lu, Yunxia |
Cancer Control |
Optimizing the Impact of Social Media to Reduce Unmet Needs for Young Adult Cancer Survivors |
Ritt-Olson, Anamara |
Cancer Control |
Interventions to Improve Lung Cancer Screening |
Sadigh, Gelareh |
Cancer Control |
Assessing the relevance of ICOS as a biomarker predicting resistance to checkpoint immunotherapy |
Tran, Thuy |
Cancer Control |
New Machine Learning Methods to Identify Metabolomic and Genomic Biomarkers for Colorectal Cancer |
Zhang, Min |
Cancer Control |
Project Title |
Investigator |
Program Area |
---|---|---|
A feasibility study for application of AI to the study of integrative oncology |
Nelson, Edward |
Biotechnology, Imaging & Drug Development |
Vascularized microtumor as a drug testing platform for peritoneal carcinomatosis |
Senthil, Maheswari |
Biotechnology, Imaging & Drug Development |
Quantification of irreversible electroporation outcomes based on longitudinal monitoring of hybrid functional/structural variations of HCC microenvironment |
Zhang, Zhuoli |
Biotechnology, Imaging & Drug Development |
An optimal dose finding study of N-Acetylcysteine in patients with myeloproliferative neoplasms |
Fleischman, Angela |
Systems, Pathways & Targets |
Identifying approaches to effectively target metastatic pancreatic cancer |
Halbrook, Christopher |
Systems, Pathways & Targets |
Effects of dietary methionine restriction on splicing in tumors |
Kaiser, Peter |
Systems, Pathways & Targets |
Elucidating epigenetic and metabolic mechanisms underlying sex differences in cancer development |
Kong, Mei |
Systems, Pathways & Targets |
Identifying early diagnosis markers and therapeutic targets of kidney tumors in young TSC patients |
Lee, Gina |
Systems, Pathways & Targets |
Defining genomic instability in early onset colorectal cancer in US-born Hispanics |
Pannunzio, Nick |
Systems, Pathways & Targets |
Functional characterization of the Hippo pathway in cancer |
Wang, Wenqi |
Systems, Pathways & Targets |
Electroacupuncture for the management of cancer-related cognitive impairment in adolescent and young adults - a pilot clinical trial |
Chan, Alexandre |
Cancer Control |
Understanding and addressing cancer survivorship needs for Filipino-Americans in Los Angeles and Orange counties |
Tanjasiri, Sora Park |
Cancer Control |
Project Title |
Investigator |
Program Area |
---|---|---|
Phase II trial of sequential systemic therapy plus intraperitoneal paclitaxel in gastric/GEJ cancer peritoneal carcinomatosis |
Senthil, Maheswari |
Biotechnology, Imaging & Drug Development |
Radiogenomics-guided personalized treatment for hormonal receptor positive metastatic breast cancer and post-neoadjuvant chemotherapy residual disease |
Su, Lydia |
Biotechnology, Imaging & Drug Development |
Personalized therapeutic cancer vaccines to effectively mobilize anti-tumor T cell immunity in non-small cell lung cancer |
Hughes, Christopher |
Biotechnology, Imaging & Drug Development |
Pathophysiological role of complement C1q in glioma |
Acharya, Munjal |
Biotechnology, Imaging & Drug Development |
Real-time dosimetric measurements for FLASH radiotherapy with acoutstic emission |
Xiang, Liangzhong |
Biotechnology, Imaging & Drug Development |
Targeted therapy in addition to salvage chemotherapy for patients with primary refractory AML as a bridge to allogeneic stell cell transplantation |
Jeyakumar, Deepa |
Systems, Pathways & Targets |
Characterizing the bioenergetic shift in triple negative breast cancer metastasis |
Lawson, Devon |
Systems, Pathways & Targets |
Assessment of clonal hematopoiesis as a predisposing factor for severe COVID-10 infection |
Fleischman, Angela |
Systems, Pathways & Targets |
Active in vivo metabolites of p53 reactivation small molecules |
Jang, Cholsoon |
Systems, Pathways & Targets |
The role of alternative pre-mRNA processing in colon cancer |
Hertel, Klemens |
Systems, Pathways & Targets |
Use of levocarnitine for asparaginase hepatotoxicity for acute lymphoblastic leukemia patients |
Huynh, Van |
Systems, Pathways & Targets |
Mechanisms of local Treg expansion in melanoma following PD-1 blockade |
Marangoni, Francesco |
Systems, Pathways & Targets |
Human lymphoma organoids as a screening platform for drug discovery and precision medicine in Non-Hodgkin lymphoma |
Wagar, Lisa |
Systems, Pathways & Targets |
A pilot study of immunotherapy combined with stereotactic ablative radiotherapy for patients with advanced or metastatic sarcoma |
Harris, Jeremy |
Cancer Control |
SHORT: UCI 20-09: SHOrt Course Radiation and TASOX (TAS102 plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer, a Phase II Trial |
Zell, Jason |
Cancer Control |
Overcoming barriers to health-information seeking behavior and potential for technology for childhood cancer survivors (CCS) |
Hayes, Gillian |
Cancer Control |
Project Title |
Investigator |
Program Area |
---|---|---|
Pilot study for evaluating the multiphoton microscopy potential for non-invasive, early diagnosis of melanoma |
Kelly, Kristen |
Biotechnology, Imaging & Drug Development |
Developing the Next Generation Antibody Drug Conjugates |
Weiss, Gregory |
Biotechnology, Imaging & Drug Development |
Melanoma Screening and Staging with a Fiber Optical Device |
Hedde, Per Niklas |
Biotechnology, Imaging & Drug Development |
Novel Inhibitors of phosphoinositide 3-kinase (PI3K) that target scaffold protein-mediated interactions |
Bardwell, Lee |
Systems, Pathways & Targets |
Restoring p53 activity in human cancer |
Qiao, Feng |
Systems, Pathways & Targets |
Dissecting MAP4K kinases in cancer development and therapy |
Wang, Wenqi |
Systems, Pathways & Targets |
Phase 2 Study of cabozantinib combined with ipilimumab/nivolumab and transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) who are not candidates for curative intent treatment |
Dayyani, Farshid |
Systems, Pathways & Targets |
A Randomized Clinical Trial to Assess the Impact of a Remotely Administered Mediterranean Diet Intervention on Symptom Burden and Inflammatory Cytokines in Myeloproliferative Neoplasm |
Fleischman, Angela |
Systems, Pathways & Targets |
Clock-dependent inflammatory and metabolic alterations in colorectal cancer |
Masri, Selma |
Systems, Pathways & Targets |
Neoadjuvant combination therapy with Cabozantinib and Nivolumab in patients with muscle-invasive urothelial carcinoma of the bladder who are Cisplatin-eligible and are candidates for radical cystectomy |
Mar, Nataliya |
Systems, Pathways & Targets |
Feasibility of a Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Hispanic Men with Testicular Cancer |
Hoyt, Michael |
Cancer Control |
The burgeoning cannabis industry and availability of cheap tobacco in Orange County, CA |
Timberlake, David |
Cancer Control |
Pilot study of the safety and feasibility of immediate postoperative chemotherapy in patients with metastatic invasive colonic adenocarcinoma |
Jafari, Mehraneh Dorna |
Cancer Control |
Factors Associated with Helicobacter Pylori Screening and Treatment among High-Risk Asians in Orange County: Mixed-Methods Research to Examine Stomach Cancer Disparity |
Lee, Sunmin |
Cancer Control |
Goal Directed Intervention for Adolescent Cancer Survivors |
Fortier, Michelle |
Cancer Control |
Project Title |
Investigator |
Program Area |
---|---|---|
Macropinocytosis drives anabolism and drug resistance in breast cancer |
Edinger, Aimee |
Biotechnology, Imaging & Drug Development |
Single-cell transcriptome analysis of human Merkel Cell Carcinoma heterogeneity by single-cell RNA sequencing |
Gao, Ling |
Biotechnology, Imaging & Drug Development |
True multi-modal image-guided intervention system |
Nouizi, Farouk |
Biotechnology, Imaging & Drug Development |
Advancing Oro-Pharyngeal Cancer Screening and Diagnosis to Overcome Disparities and Improve Control and Outcomes |
Wilder-Smith, Petra |
Biotechnology, Imaging & Drug Development |
Experimental Therapeutics for Primary Pediatric Brain Tumors |
Plant, Ashley |
Biotechnology, Imaging & Drug Development |
Role of Phosphatase Methylation in One-Carbon Metabolism and Cancer |
Kaiser, Peter |
Systems, Pathways & Targets |
A Phase 1b study of TAS102 in combination with irinotecan in patients with advanced gastric and gastroesophageal adenocarcinoma |
Dayyani, Farshid |
Systems, Pathways & Targets |
A phase I study of pitavastatin in combination with venetoclax for chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML) |
Brem, Elizabeth |
Systems, Pathways & Targets |
UHRF1 as a therapeutic target for osteosarcoma |
Benavente, Claudia |
Systems, Pathways & Targets |
Molecular mechanism of APOBEC3B-Mediated Mutation Shower in Ovarian Cancer |
Buisson, Remi |
Systems, Pathways & Targets |
Control of B cell survival & transformation by the eIF4F translation initiation complex |
Fruman, David |
Systems, Pathways & Targets |
Improving Depression Screening in a Multi-ethnic Cancer Population |
Wenzel, Lari |
Cancer Control |
DNA methylation markers for exposures to BPA and related compounds and breast cancer risk |
Park, Hannah Lui |
Cancer Control |
The relationship between the gut microbiome and the efficacy of immune checkpoint inhibitors in patients with gynecologic malignancy |
Tewari, Krishnansu |
Cancer Control |
A mechanistic study of age-dependent gender difference in melanoma risk |
Liu-Smith, Feng |
Cancer Control |
Development and Testing of a Mobile Application for Young Adults with Cancer |
Hoyt, Michael |
Cancer Control |
Project Title |
Investigator |
Program Area |
---|---|---|
RhoJ Inhibitors- A Novel Treatment for Early Stage Melanoma |
Ganesan, Anand |
Biotechnology, Imaging & Drug Development |
Pilot study of mirtazapine for the dual treatment of depression and temozolomide-induced nausea and vomiting (CINV) in newly-diagnosed glioma patients |
Bota, Daniela |
Biotechnology, Imaging & Drug Development |
Identifying the anti-neoplastic targets of SH-BC-893 |
Edinger, Aimee |
Biotechnology, Imaging & Drug Development |
Immunotherapeutic’s targeting altered N-glycosylation in cancer |
Demetriou, Michael |
Biotechnology, Imaging & Drug Development |
Glutamine supplementation deters melanoma tumor growth via epigenetic reprogramming |
Kong, Mei |
Systems, Pathways & Targets |
Repurposing statins to enhance efficacy of BH3 mimetics in multiple myeloma |
Fruman, David |
Systems, Pathways & Targets |
Circadian Metabolic Deregulation of Colorectal Cancer |
Masri, Selma |
Systems, Pathways & Targets |
Feasibility Study of a Mediterranean Diet Intervention to Reduce Inflammatory Cytokines in Patients with Myeloproliferative Neoplasms |
Fleischman, Angela |
Systems, Pathways & Targets |
Pilot Study of the Safety and Feasibility of Immediate Adjuvant Chemotherapy in Patients with Invasive Colonic Adenocarcinoma |
Pigazzi, Alessio |
Systems, Pathways & Targets |
Analysis of Hippo signaling in breast cancer development |
Wang, Wenqi |
Systems, Pathways & Targets |
Modulation of the Immune Response Against Metastatic Melanoma Using CD47 Blocking Antibodies |
Boiko, Alexander |
Systems, Pathways & Targets |
Feasibility of a Family Focused Intergenerational Social Media Intervention for Orange County Vietnamese Families to Increase Preventive Cancer Screenings |
Hopfer, Suellen |
Cancer Control |