Precision Approaches in Radiation Synthetic Combinations (PAIRS) (R01 Clinical Trial Optional)

PAR-22-198. Multiple application deadlines. LOI due 30 days before application due date. Earliest LOI due date (new): Sept 5, 2022.

Through this Funding Opportunity Announcement (FOA) entitled, “Precision Approaches in Radiation Synthetic combinations (PAIRS)", the National Cancer Institute (NCI) solicits research projects that examines actionable vulnerabilities created by cancer reprogramming in association with responses to radiation therapy. The PAIRS program will support projects that range from pre-clinical research to early clinical trials that develop radiation treatment-based synthetic combination strategies and facilitate their adoption into the precision medicine toolkit toward building new and effective anticancer treatments.

This FOA utilizes the Research Project Grant (R01) mechanism and runs in parallel with a companion FOA of identical scope, PAR-22-199, which utilizes the Research Exploratory/Developmental Research Grant (R21) mechanism.