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Shared Resources

The UC Irvine Chao Family Comprehensive Cancer Center's Shared Resources help foster innovative research into the causes, diagnosis and treatment of cancer.

The Chao Family Comprehensive Cancer Center currently provides seven Shared Resources. It is very important to the continued funding of the Chao Family Comprehensive Cancer Center that the productive collaboration of CFCCC Shared Resources is acknowledged in publications and presentations, and that resulting publications comply with the National Institutes of Health public access policy.

Guidelines for Shared Resource Acknowledgement

Suggested acknowledgement text:

“The authors wish to acknowledge the support of the Chao Family Comprehensive Cancer Center <SHARED RESOURCE NAME HERE> Shared Resource, supported by the National Cancer Institute of the National Institutes of Health under award number P30CA062203. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”

Biobehavioral Shared Resource Facility »

Biobehavioral Shared Resource Facility

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The Biobehavioral Shared Resource (BBSR) provides a consultative service to assist researchers as they incorporate patient/participant reported outcomes into their projects. This support includes expertise on patient-reported outcome (PRO) instrument selection, PRO instrument development, and consideration for data collection assessment intervals and strategies to obtain valid and reliable PRO data. The BBSR has expanded service to include focus group design and conduct, offered in English and Spanish.

Biostatistics Shared Resource »

Biostatistics Shared Resource

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The Biostatistics Shared Resource (BSR) supports the conception, design, implementation, analysis and reporting of research conducted by members of the Chao Family Comprehensive Cancer Center. In addition, BSR faculty serve as liaisons to each of the cancer center’s Disease-Oriented Teams, keeping abreast of team developments and providing a first point of contact for assistance from the BSR with study design, data analysis, and new grant development.

Experimental Tissue Shared Resource Facility »

Experimental Tissue Shared Resource Facility

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The Experimental Tissue Shared Resource (ETR) provides basic, translational and clinical cancer center researchers access to, and analysis of, human and animal tissues. ETR leverages the technical and professional expertise of the Department of Pathology and Laboratory Medicine, offering four component services: Routine tissue histology/immunohistochemistry (IHC); tissue analysis, including laser capture microscopy (LCM); mouse pathology services; and genotyping services.

Genomics High-Throughput Facility »

Genomics High-Throughput Facility

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The Genomics High-Throughput Facility (GHTF) provides genome-wide analysis for clients interested in gene expression, regulation of gene expression, and genome sequence and variation. The primary forms of genome-wide analysis are the Affymetrix GeneChip, Illumina HiSeq 2500 next generation sequencing and PacBio RS real-time single molecule sequencing. Through campus shared resources, services for other technologies include NanoString and Ion Torrent PGM. The GHTF has expanded and currently provides services to numerous outside academic and non-profit institutions, as well as commercial biotech entities.

In-Vivo Functional Onco-Imaging »

In-Vivo Functional Onco-Imaging

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The In-Vivo Functional Onco-Imaging (IVFOI) shared resource supports basic and clinical cancer researchers by providing them with the necessary expertise, imaging instrumentation, and image analysis techniques. In addition to providing services with standard preclinical and clinical imaging systems available at most institutions, the IVFOI works to integrate molecular and structural imaging modalities to provide exclusive, first-of-its-kind multi-modality imaging technologies, providing  for a better understanding of the fundamental biochemical nature of cancer and for development of new contrast agents and molecular pathway-specific imaging probes.

Optical Biology Core »

Optical Biology Core

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The Optical Biology Core (OBC) operates under the theme that technology enables discovery. Consequently, the goal of the OBC is to provide the best conventional microscopy platforms available and to develop and introduce novel optical methods that allow new discoveries to be made. OBC comprises three facilities on the UC Irvine campus: i) a self-use OBC facility equipped with fluorescence microscopes and image analysis software, ii) the Laser Microbeam and Medical Program (LAMMP), a collaborative facility dedicated to the use of lasers and other optics in Biology and Medicine, and iii) a flow cytometry facility in Hewitt Hall equipped with three multiparameter flowcytometers.

Transgenic Mouse Facility »

Transgenic Mouse Facility

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The Transgenic Mouse Facility (TMF) – Mouse Genome Engineering Facility (MGEF) develops and provides services for making, breeding, genotyping, importing, and preserving genetically modified mice on a recharge basis. The TMF also offers advice and practical instruction in use of genetically modified mice in biological and biomedical research, including Cancer Research. In addition to supporting UCI investigators, approximately 50% of the services are provided to off-campus investigators at academic and commercial institutions throughout the USA, including several additional NCI-Designated Comprehensive Cancer Centers. The TMF has extensive experience in Cas9/gRNA-based methodology to modify the mouse genome, having completed over 80 such projects as of August 2019. Popular Cas9-mediated editing projects include production of mice with missense mutations, reporter or other coding sequence knocked-in, and production of floxed conditional knockout alleles. Other services offered by the TMF include production of genetically-modified animals via pronuclear microinjection, development of ES cell derived gene-targeted modifications, embryo and sperm cryopreservation and reanimation, and genotyping. We also offer services in targeted transgenesis (at ROSA26 and H11), BAC transgenesis, development of new lines of ES cells, chromosome counting services, Southern analysis, advice on molecular cloning services to develop BAC constructs, and development of genotyping assays. A powerful, but under-appreciated service offered by the TMF is production of cohorts of age-matched experimental and control mice via hyper-ovulation, IVF and embryo transfer techniques. A strength of the TMF is its ability to partner with PI's to develop robust and successful strategies to analyze genetic function using the mouse. Since its inception in 1996, the TMF has generated hundreds of lines of genetically modified mice.

Additional University of California Cancer Center Shared Resources

To find shared research core facilities provided by the other University of California Cancer Centers (UC Davis, UCLA, UCSD and UCSF), visit: please click here