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What is a Disease-Oriented Team (DOT)?

A Disease-Oriented Team (DOT) is a multidisciplinary group of clinical, basic and translational researchers who collaborate around a specific anatomic cancer area to further the translation of Cancer Center discoveries (e.g. new targets, biomarkers, drugs, biological agents, diagnostic and therapeutic devices) through the pipeline towards interventional clinical trials. Because of their collective expertise, DOTs steward the Cancer Center's clinical research efforts, managing the clinical trials portfolio around the following principles: scientific merit, soundness of trial design, accrual potential, and likelihood for correlative translational science.

What does a DOT do?

  • Facilitate the translation of scientific discoveries to address specific types of cancer
  • Promote multidisciplinary collaboration to address disease-specific questions
  • Determine interest in and commitment to a trial and the potential to accrue
  • Ensure adequate internal review of scientific quality and feasibility of clinical trials, and oversees prioritization of protocols
  • Review clinical research portfolio and develops and brings forward new trials, including investigator-initiated trials
  • Catalyze new multi-investigator, multidisciplinary preclinical and clinical translational research

Have a clinical study you'd like to launch?

All clinical studies in cancer must undergo a feasibility review by the corresponding DOT or Tumor Board. To submit a study for review, download and complete the application and email to CancerCenter_Committees@health.uci.edu.

Our current DOTs

For meeting times and locations, please see the administrative contacts listed below.

Breast Oncology »


Devon Lawson, PhD
Erin Lin, DO
Ritesh Parajuli, MD

Meeting Frequency: Monthly, typically the last Tuesday, at the UC Irvine Medical Center.

Gastrointestinal Oncology »


Mehraneh Dorna Jafari, MD
Jason Zell, DO

Meeting Frequency: Monthly, typically the 4th Tuesday, at the UC Irvine Medical Center.

Genitourinary Oncology »


Edward Uchio, MD
Michael McClelland, PhD

Meeting Frequency: Monthly, alternating between the 4th Wednesday and the 4th Friday, at the UC Irvine Medical Center.

Gynecologic Oncology »


Fabio Cappuccini, MD
Lydia Su, PhD

Meeting Frequency: Monthly, typically on the last Friday, at the UC Irvine Medical Center.

Hematologic Malignancies »


Angela Fleischman, MD, PhD
Deepa Jeyakumar, MD

Meeting Frequency: Monthly, typically on the first Thursday, at the UC Irvine Medical Center.

Neuro-Oncology »


Daniela Bota, MD, PhD
Frank Hsu, MD, PhD

Meeting Frequency: Monthly, typically the 1st Friday, at the UC Irvine Medical Center.

Skin Cancer »


Ken Linden, MD
Bogi Andersen, MD

Meeting Frequency: Monthly, the 1st or 2nd Monday or 2nd Wednesday, alternating between the UC Irvine Medical Center and the main campus in Irvine.

Administrative Contact

For more information on the DOTs, please email: